Sertraline Breastfeeding Warnings
Sertraline is excreted into human milk. Adverse effects in the nursing infant are unlikely. The manufacturer recommends that caution be used when administering sertraline to nursing women.
A study of fourteen mother- infant pairs reported that even though mothers receiving clinical doses of sertraline experienced substantial blockade of the platelet 5-HT transporter, platelet five-HT uptake in nursing infants of treated mothers was unaltered. Another study of twelve breast-feeding mothers reported that both sertraline and desmethylsertraline were present in all breast milk samples. Detectable levels of sertraline were reported in 3 nursing infants and detectable levels of desmethylsertraline had been reported in six infants. The data from a single study on 3 breast- fed infants suggested that sertraline and/or its practically inactive metabolite norsertraline may be present at quite low concentrations in the plasma of breast- fed infants. No adverse effects had been noted in the infants. A case study of a mother breast-feeding whilst receiving sertraline therapy has also been reported. The drug was found to be present in the mother?s milk. However, no sertraline was detected in the infant?s serum and no abnormal occurrences had been noted in the development of this infant either.
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Source: http://articlepdq.com/health-fitness/zoloft-lawyer/
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